The opening store scene does a lot, with Seth Rogen's story about a Tijuana show featuring a woman and a horse, which turned out not as cool as it sounds.
Paul Rudd accosting Jane Lynch over the Michael McDonald DVD, ending with the 'Yamo burn this place to the ground' line; the speaker's son got bored about 40 minutes in but watched that bit on YouTube over and over.
The same DVD played over and over in the store is very real to anyone who has worked retail.
The poker game feels like an SNL sketch; the line about a breast feeling like a bag of sand makes it the speaker's personal favorite scene.
The Leslie Mann scene is bonkers, the only unrealistically unhinged scene, but in a good way.
The body-waxing scene was like Caddyshack's Baby Ruth scene coming out of the theater.
The hosts say the waxing was done for real with five cameras and an actress as the waxer, so the nipple was not oiled and his right nipple was ravaged; it was really Carell's chest, and they had to keep waxing it for later shirtless scenes.
Paul Rudd bringing over a big box of porn and the Boner Jams '03 mix tape, followed by the Everybody Loves Raymond tape; Boner Jams '03 is called the favorite line in the movie.
The speed dating scene is really good, with Mo Collins's character flagged to come up later for the Dion Waiters category.
Andy's first date call to Catherine Keener while the others do 'you know how I know you're gay', which has not aged well in some ways but is Rudd and Rogen cooking.
The support group scene and Seth with his dad, who berates him about his little Jew fro.
The ending, where losing his virginity turns into a musical number with the whole cast, is called a really good choice and credited to Gary Shandling because they couldn't figure out the ending.
A special shout-out goes to the extended version of the Kevin Hart and Malco scene, compared to Clemens and Cecil Fielder going toe to toe; the lister agrees and had it in what's aged the best.
Andy following Rogen's character's tips in the bookstore: the just-ask-questions bit, the 'be David Caruso in Jade' advice, then the best line in the movie and the 90-second seduction by Elizabeth Banks.
The David Caruso in Jade reference may have aged best or worst, since producer Craig would not know what Jade was.
Formal pick: the poker game, because it is perfectly written.
A second voice agrees the poker game is the most iconic now: the chest waxing was, but the bag-of-sand line is the one quoted back.
It fits the movie because the other guys' sex talk makes sex seem gross and foreign, so Andy's choice to stay home with his electronic drum kit seems understandable.